basic FUNCTION
| adenosine receptor B2, activating adenylate cyclase |
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stimulating adenylate cyclase activity in the presence of adenosine |
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may have a significant role in the pathogenesis of the neurological manifestations of Lesch-Nyhan syndrome (Garcia 2009) |
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poor A2BR expression at the cell surface might be accounted for mainly by the lack of a dominant forward transport signal from the endoplasmic reticulum to the plasma membrane |
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ADORA1 and ADORA2B are both involved in differentiation to Treg, but through different mechanisms |
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is a new regulator of osteoblast differentiation, bone formation, and fracture repair |
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is a significant regulator of high cholesterol diet (HFD)-induced hallmarks of Type 2 Diabetes |
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is a regulator of adipocyte differentiation and the ADORA2B-KLF4 axis is a potentially significant modulator of adipose biology |
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ADORA2B signaling mediates different types of cardioprotection in a tissue-specific manner |
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following TLR stimulation, macrophages upregulate ADORA2B to enhance their sensitivity to immunosuppressive extracellular adenosine |