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FLASH GENE
Symbol MNDA contributors: mct - updated : 09-09-2019
HGNC name myeloid cell nuclear differentiation antigen
HGNC id 7183
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage Homo sapiens
cell lineage myeloid cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DAPIN domain
  • one HIN-200 domain
  • a pyrin domain that functions in signaling associated with programmed cell death and inflammation
  • HOMOLOGY
    interspecies homolog to murine Ifi201, Ifi202
    intraspecies homolog to IFI16
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text nuclear in interphase, only in nuclei of cells of the granulocyte-monocyte lineage
    basic FUNCTION
  • participating in blood cell-specific responses to interferons
  • may be acting as a transcriptional activator/repressor in the myeloid lineage
  • MNDA and related proteins appear to modulate the activity of transcription factors and in some cases have a role in mediating cell death
  • has likely a role regulating programmed cell death in myeloid progenitor cells, and its down-regulation in myelodysplastic syndromes (MDS) is related to granulocyte-macrophage progenitor cell sensitivity to TNFSF10-induced programmed cell death
  • role of FGF4 and MNDA in pluripotent cell responses to genotoxicity
  • is a nuclear protein that labels myelomonocytic cells as well as B lymphocytes that localize to the marginal zone areas of splenic white pulp
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FCRL4 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs)
  • is useful in the differential diagnosis of marginal zone lymphomas with follicular lymphoma
  • Therapy target
    ANIMAL & CELL MODELS