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FLASH GENE
Symbol PRKAA2 contributors: shn/ - updated : 10-04-2015
HGNC name protein kinase, AMP-activated, alpha 2 catalytic subunit
HGNC id 9377
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an alpha catalytic subunit
  • non-catalytic beta and gamma subunits
  • conjugated PhosphoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to Prkaa2, Rattus norvegicus
    ortholog to PRKAA2, Pan troglodytes
    ortholog to Prkaa2, Mus musculus
    ortholog to prkaa2, Danio rerio
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • SNF1 subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • nuclear translocation might mediate the effects of exercise on skeletal muscle gene and protein expression
  • translocated into the nucleus during muscle differentiation
  • localized both in the nucleus and the cytoplasm
  • basic FUNCTION
  • responsible for acting as a metabolic sensor for AMP levels
  • a highly conserved sensor of cellular energy status
  • important for whole-body insulin action in vivo
  • associated with tight junction assembly and regulates epithelial polarity
  • has pivotal roles in the establishment of cell polarity and cell division
  • regulates microtubule dynamics through CLIP-170 phosphorylation
  • involved in the pathogenesis of Alzheimer disease
  • controls cardiac RPS6KB1 under normoxia and regulates EEF2 but not the MTOR-RPS6KB1 pathway during ischemia
  • activation of PRKAA2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylates and inhibits acetyl-coenzyme A (CoA) carboxylase (ACC) and enhances GLUT-4 translocation
  • phosphorylates HNF4alpha and represses its transcriptional activity
  • thyroid hormone receptor interactor 6, TRIP6
  • CAP-GLY domain containing linker protein 1, CLIP1
  • selective activation of the PRKAA2 by NPPA is essential for NPPA mediated lipolysis in adipocytes and has several important potential implications which are relevant to the role of NPPA in exercise, heart failure and obesity and insulin resistance
  • DCLRE1C physically interacts with PRKAA2
  • DCLRE1C promote STK11-mediated phosphorylation and activation of AMPK by stabilizing the STK11–PRKAA2 complex
  • exerts its anti-inflammatory effects through PARP1 and BCL6
  • down-regulated PRKAA2 under high glucose culture conditions via the ubiquitin-proteasome pathway
  • directly interact with the heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
  • cell & other
    REGULATION
    activated by leptin in skeletal muscle
    LKB1 serine/threonine kinase
    Other regulated by serine/threonine kinase 11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • significantly associated with serum lipoproteins in a large sample of normal female Caucasians
  • to type 2 diabetes
  • Variant & Polymorphism SNP , other
  • variants are significantly associated with serum lipoproteins in a large sample of normal female Caucasians (variants are significantly associated with serum
  • lipoproteins in a large sample of normal female Caucasians)
  • SNP influencing insulin resistance and susceptibility to type 2 diabetes in the Japanese population
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    interaction between AMPK and CLIP-170 might be a therapeutic target for treatment of conditions such as cancer, tumour angiogenesis and neointimal hyperplasia
    ANIMAL & CELL MODELS
  • AMPKalpha2(-/-) mice display high glucose levels in the fed period and during an oral glucose challenge associated with low insulin plasma levels and have reduced insulin-stimulated whole-body glucose utilization