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FLASH GENE
Symbol CDC27 contributors: mct - updated : 18-12-2013
HGNC name cell division cycle 27
HGNC id 1728
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrainmidbrainsubstantia nigra  
Respiratorylung    
Urinarykidney    
Visualeyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine tetratricopeptide repeats (TPR )
HOMOLOGY
interspecies homolog to yeast S.cerevisiae CDC27
homolog to murine Cdc27
Homologene
FAMILY CDC27/NUC2 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • may be involved in controlling the timing of mitosis
  • its phosphorylation, in response to TGFB signaling can facilitate the activation of anaphase-promoting complex (APC/cyclosome)
  • CDC27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to maintain chromosomal integrity
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the APC/C) which is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • small molecule
    protein
  • RB binding
  • CDC27 directs CCND1 to alternative degradation by APC/C
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • MCPH1 can recognize phosphorylated CDC27 via its tandem BRCT domains, and interaction between MCPH1 and CDC27 is dependent on the phosphorylation of CDC27
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CDC27 and PTTG1 appear promising biomarkers for applications in predicting disease progression, prognostication of breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential target in anti-mitotic drug development
    ANIMAL & CELL MODELS