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FLASH GENE
Symbol TIE1 contributors: mct - updated : 07-12-2013
HGNC name tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
HGNC id 11809
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselscapillary   
Lymphoid/Immunelymphatic vessel    
Reproductivefemale systemplacenta    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningendothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text
  • specifically expressed in developing vascular endothelial cells
  • in chorionic villi tree during early pregnancy
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three fibronectin-type III homology domains
  • thre EGF-like domains
  • two Ig-like C2-type (immunoglobulin-like) domains
  • HOMOLOGY
    Homologene
    FAMILY TYR protein kinase family, TIE subfamily
    CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • receptor tyrosine kinase, same class as TEK (see symbol)
  • involved in angiogenesis
  • may play a novel proinflammatory role in atherosclerosis
  • its deficiency induces endothelial-mesenchymal transition
  • endothelial cell-specific tyrosine kinase receptor, which maintains vascular integrity and regulates angiogenesis via modulating angiopoietin/TEK signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIE1-TEK interactions are dynamic, inhibitory, and differentially modulated by ANGPT1 and ANGPT2
  • molecular balance between receptor tyrosine kinases TIE1 and TEK is dynamically controlled by VEGF and TNF and regulates angiopoietin signalling
  • expression level of TIE1 and its physical interaction with TEK defines whether ANGPT2 functions as a TEK2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to ANGPT2
  • under hypoxic conditions, TIE1 is critical for reducing ANGPT1-induced TEK activity and angiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukemia with early chronic phase and shorter survival
    constitutional     --low  
    in serum may serve as a marker of proliferative vasculopathy in systemic sclerosis (SSc) with disease duration of >6 years
    tumoral     --low  
    endothelial-mesenchymal transition (EndMT) associated with TIE1 downregulation participates in the pathological development of stroma observed in tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS