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FLASH GENE
Symbol APOBEC1 contributors: mct/npt - updated : 28-03-2018
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
HGNC id 604
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mooring sequence to promote editing of an appropriably located cytidine
  • a C terminal leucine rich region
  • alpha helix
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Apobec1
    homolog to E.coli Cda
    intraspecies homolog to APOBEC2
    Homologene
    FAMILY
  • RNA-editing deaminase family
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nucleo-cytoplasmic trafficking protein
    basic FUNCTION
  • responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA
  • editing HBV DNA (Gonzalez 2009)
  • act through an RNA-interacting cofactor, APOBEC1 complementation factor (ACF) (Nonaka 2009)
  • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • part of the apolipoprotein B mRNA editing complex
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Zn2+
  • protein
  • interacting with A1CF)
  • BAG4 binds to APOBEC1 via its N-terminal region independent of the BAG domain
  • SYNCRIP is involved in viral replication, neural morphogenesis, modulation of circadian oscillation, and the regulation of the cytidine deaminase APOBEC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    phosphorylation of ACF (APOBEC-1 complementation factor) by PKC may be a key regulatory mechanism of APOBEC1 in rat hepatocytes (Lehmann 2007)