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FLASH GENE
Symbol DUSP5 contributors: mct - updated : 09/12/2008
HGNC name dual specificity phosphatase 5
HGNC id 3071
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivestomach   moderately
Endocrinethyroid   moderately
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Connectivebone  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to rattus Dusp5 (92.7 pc)
    homolog to murine Dusp5 (93.5 pc)
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • dual specificity protein phosphatase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • displaying phosphatase activity toward several substrates, the highest relative activity is toward ERK1
  • playing a critical role for normal immune system development, IL-2 actions and tolerance
  • being an inducible nuclear ERK-specific MAP kinase phosphatase
  • functioning as both an inactivator of and a nuclear anchor for ERK2
  • DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • protein amino acid dephosphorylation
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TP53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice overexpressing DUSP5 (Kovanen, 2008)