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FLASH GENE
Symbol CDA contributors: mct/npt - updated : 28-02-2009
HGNC name cytidine deaminase
HGNC id 1712
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
 fibroblast
Blood/Hematopoieticgranulocyte
Blood/Hematopoieticmonocyte
cell lineage
cell lines nucleotide cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytically important zinc finger domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Rn.6887
    homolog to C.elegans C47D2.2
    homolog to murine 2210401N16Rik
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzes the deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively (Lisboa 2007)
  • scavenging exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
  • deaminating and irreversibly deactivating the chemotherapeutic agent cytosine arabinoside (Ara-C), a deoxycytidine analog used for treatment of acute leukemias and lymphomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotides and nucleic acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS