Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CSNK1A1 contributors: mct - updated : 19-10-2017
HGNC name casein kinase 1, alpha 1
HGNC id 2451
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • S-insert located at the C terminus
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY serine/threonine protein kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text cell surface receptor linked
    basic FUNCTION
  • casein kinase 1, catalytic unit alpha 1, involved in the regulation of the G1-checkpoint at the cyclin-dependent kinase inhibitor CDKN1A
  • another kinase that regulates RIPK1 function in NF-kappaB activation
  • plays a major role in the phosphorylation of TP53 at threonine residue (Thr18) within the Mdm2/4-binding domain
  • functions as a conditionally essential malignancy gene-a member of a new class of potential cancer therapeutic targets
  • regulates several fundamental cellular processes including proliferation and differentiation
  • nuclear form playing a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS development
    text putatively involved in generation of complete dorsal axes and induction of genes that are direct targets of WNT signals
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    sphingolipid metabolism, capable of mediating G protein coupled receptor (GPCR) phosphorylation
    a component CSNK1A1 and MDM2 form a stable complex suggesting that the MDM2/CSNK1A1 complex is a component of a genetic pathway that co-regulates the stability of the TP53 and E2F-1 transcription factors
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • preferentially acidic proteins, broadly specificity
  • FADD-CSNK1A1 association regulates the subcellular localization of FADD, and phosphorylated FADD was found to colocalize with CSNK1A1 on the spindle poles in metaphase
  • interacted with and phosphorylated RIPK1 at the intermediate domain
  • interacts with endogenous TP53 and PML, and this interaction is enhanced by genotoxic stress
  • phosphorylates RHOB in vitro but not RhoA or RhoC
  • major IFNAR1 kinase that confers basal turnover of IFNAR1 and cooperates with ER stress stimuli to mediate phosphorylation-dependent degradation of IFNAR1
  • dynamically associates with the CBM (CARD11, the adaptor BCL10 and the paracaspase MALT1) complex on T-cell-receptor (TCR) engagement to participate in cytokine production and lymphocyte proliferation
  • stably associates with MDM4, stimulates MDM4-TP53 binding, and cooperates with MDM4 to inactivate TP53
  • CSNK1A1 mediates FAM83H-dependent reorganization of keratin filaments
  • FAM83H acts as a scaffold protein that recruits CSNK1A1 to the keratin cytoskeleton or to the nuclear speckles, which are storage sites for splicing factors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in DMD with milder phenotype
    constitutional       gain of function
    of CSNK1A1 results in accumulation of MDM2 and decreased TP53 activity, and resistance to apoptosis induced by DNA damaging agents
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS