protein
| preferentially acidic proteins, broadly specificity |
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FADD-CSNK1A1 association regulates the subcellular localization of FADD, and phosphorylated FADD was found to colocalize with CSNK1A1 on the spindle poles in metaphase |
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interacted with and phosphorylated RIPK1 at the intermediate domain |
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interacts with endogenous TP53 and PML, and this interaction is enhanced by genotoxic stress |
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phosphorylates RHOB in vitro but not RhoA or RhoC |
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major IFNAR1 kinase that confers basal turnover of IFNAR1 and cooperates with ER stress stimuli to mediate phosphorylation-dependent degradation of IFNAR1 |
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dynamically associates with the CBM (CARD11, the adaptor BCL10 and the paracaspase MALT1) complex on T-cell-receptor (TCR) engagement to participate in cytokine production and lymphocyte proliferation |
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stably associates with MDM4, stimulates MDM4-TP53 binding, and cooperates with MDM4 to inactivate TP53 |
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CSNK1A1 mediates FAM83H-dependent reorganization of keratin filaments |
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FAM83H acts as a scaffold protein that recruits CSNK1A1 to the keratin cytoskeleton or to the nuclear speckles, which are storage sites for splicing factors |