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FLASH GENE
Symbol CDK11A contributors: mct/pgu - updated : 27-06-2016
HGNC name cyclin-dependent kinase 11A
HGNC id 1730
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemovary  highly
Respiratorylung    
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
life cycle division
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a helicase ATP-binding domain
  • a helicase c-terminal domain
  • HOMOLOGY
    interspecies homolog to Drosophila Pitslre
    homolog to C.elegans B0495.2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing roles in cell apoptosis
  • a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
  • exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
  • interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
  • CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
  • CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
  • involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    constitutional     --low  
    caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death
    Susceptibility to type 2 diabetes in a Han Chinese cohort
    Variant & Polymorphism SNP SNP11 strongly associated with female patients with T2D
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS