Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CDK11A

contributors: mct/pgu - updated : 27-06-2016

HGNC name	cyclin-dependent kinase 11A
HGNC id	1730

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly Reproductive female system ovary     highly Respiratory lung         Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

life cycle

division

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a helicase ATP-binding domain
	a helicase c-terminal domain

HOMOLOGY

interspecies	homolog to Drosophila Pitslre
	homolog to C.elegans B0495.2

Homologene

FAMILY	protein kinase superfamily
	CMGC Ser/Thr protein kinase family
	CDC2/CDKX subfamily

CATEGORY

enzyme , receptor serine/threonine kinase

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	playing roles in cell apoptosis
	a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
	exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
	role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis

CELLULAR PROCESS	cell cycle
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	cell cycle control

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
	interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
	CDK11A that is broadly distributed onto chromatin and phosphorylates the MED27 and MED4 Mediator subunits on conserved residues
	CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
	CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
	involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in neuroblastoma constitutional     --low   caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death

Susceptibility

to type 2 diabetes in a Han Chinese cohort

Variant & Polymorphism SNP	SNP11 strongly associated with female patients with T2D

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS