| SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| text
| IFI30 and CTSS colocalized within lysosomes of B cells  |
| basic FUNCTION
| cysteine protease having a central role in remodeling the extracellular matrix and implicated in the etiology of cardiovascular disease |
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cysteine endoprotease specifically involved in MHCII-associated chain processing and peptide loading |
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lysosomal cysteine proteinase may be participating in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules |
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playing a specific role in the generation of antigenic peptides |
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playing a functional role in angiogenesis and neoplastic progression |
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having a potential role to promote preadipocyte differentiation |
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may promote adipogenesis, at least in part, by degrading fibronectin in the early steps of differentiation, and having a possible contribution to fat mass expansion in obesity |
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may play a role in determining the Apo-A1 and HDL-C profiles and may thus influence reverse cholesterol transport |
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may play a role in the activation of an adoptive immune response |
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with CTSL, and CTSK, implicated in atherogenesis |
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importance of CTSB, CTSS and Cystatins in immunomodulation |
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in lysosomes is essential for mitophagy processing in macrophages |
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CTSB, CTSK, CTSL1, CTSS may be putative leptin activity regulators in white adipose tissue (WAT) |
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has a much lower binding affinity and catalytic rate for collagen I and cleaves only at the telopeptide regions of the molecule, regions that are increasingly exposed after hydrolysis by CTSK |
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may participate in basement membrane (BM) proteolysis, in addition to already identified proteases |
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physiologic mechanism that regulates CTSS and has implications for fine tuning MHC class II-restricted Ag processing and for the development of CTSS inhibitors, which are under investigation for the treatment of autoimmune disease |
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may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases |
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CTSS secreted by microglia during the dark-phase decreases the spine density of the cortical neurons by modifying the perisynaptic environment, leading to downscaling of the synaptic strength during the subsequent light-phase |
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peripheral pivotal role of CTSS in the development of neuropathic pain through the antigen-specific activation of CD4(+) T-cells |
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tumor-promoting role of autophagy in tumor-associated macrophages (TAMs), suggesting CTSS could be a potential target for cancer therapy |
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cysteine protease that controls adipocyte differentiation and has been implicated in vascular and metabolic complications of obesity |
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CTSZ is the compensatory protease that regulates the acquired tumor-promoting functions of lesions deficient in both CTSB and CTSS |
