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FLASH GENE
Symbol TFCP2 contributors: mct/ - updated : 24-12-2009
HGNC name transcription factor CP2
HGNC id 11748
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to Drosophila transcription factor Elf-1/NTF-1
intraspecies homolog to UBP1
Homologene
FAMILY
  • grh/CP2 family
  • CP2 subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text exclusively localized in the cytosol
    basic FUNCTION
  • possible trancriptional regulator of immunodeficiency virus type 1
  • recognizing several distinct binding motifs by virtue of employing different regions, thus being able to interact with and regulate many cellular partners
  • playing an important role in the regulation of erythroid genes
  • exhibiting some tissue- or stage-specific activation toward certain genes such as globin in red blood cells and interleukin-4 in T helper cells
  • critical regulator of erythroid gene expression
  • role in fibronectin expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with NFE2 to form the stage selector protein complex
  • heterodimerization with UBP1 is necessary for nuclear localization
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSKB, APBB1 (FE65) and others involved in the inflammatory response
  • two HXPR motif-containing proteins REST and YY1 were able to bind TFCP2
  • interacting with RNF2 and PHB2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
  • TFCP2 is an essential transcription factor for SRY expression regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP 3'utr G>A protective effect of A allele
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS