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FLASH GENE
Symbol SLC25A3 contributors: shn - updated : 20-12-2013
HGNC name solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
HGNC id 10989
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family (3 solcar repeats)
  • N-terminal and C-terminal regions protrude toward the cytosol
  • HOMOLOGY
    interspecies ortholog to Slc25a3, Mus musculus
    ortholog to Slc25a3, Rattus norvegicus
    ortholog to SLC25A3, Pan troglodytes
    Homologene
    FAMILY mitochondrial transporter family SLC25
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text localized in mitochondrial matrix
    basic FUNCTION
  • catalyzing the uptake of phosphate in symport with a proton
  • involved in the terminal steps of oxidative phosphorylation (OXPHOS)
  • transports inorganic phosphate into the mitochondrial matrix, which is essential for the aerobic synthesis of adenosine triphosphate (ATP)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text catalyzes the transport of phosphate into the mitochondrial matrix
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) MPCD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS