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FLASH GENE
Symbol PTS contributors: - updated : 27-12-2005
HGNC name 6-pyruvoyltetrahydropterin synthase
HGNC id 9689
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Reproductivemale systemprostate  highly
Urinarybladder   highly
 kidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , hexamer
HOMOLOGY
Homologene
FAMILY PTPS family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • 6-pyruvoyl-tetrahydrobiopterin synthase, catalyzing the second step of tetrahydrobiopterin (BH4) synthesis
  • involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homohexamer formed of two homotrimers in a head to head fashion
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PTSD
    related resource 6-Pyruvoyl-tetrahydropterin synthase deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS