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FLASH GENE
Symbol HIVEP3 contributors: mct/npt - updated : 11/09/2009
HGNC name human immunodeficiency virus type I enhancer binding protein 3
HGNC id 13561
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   moderately
Endocrinethyroid   highly
Lymphoid/Immunelymph node   moderately
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
Respiratorylung    
 respiratory tractlarynx  moderately
Urinarykidney    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • two C2H2 zinc finger binding domains
  • a C-terminal DNA-binding domain
  • a leucine zipper
  • ZAS1 and ZAS2 domains
  • GTPase motifs
  • HOMOLOGY
    interspecies ortholog to rattus Hivep3 (82.7pc)
    ortholog to murine Hivep3 (81pc)
    intraspecies paralog to HIVEP1
    paralog to HIVEP2
    Homologene
    FAMILY
  • Schnurri protein family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulating transcription via the kappa-B enhancer motif
  • being a participant in the signal transduction pathway leading from the TNF receptor to gene activation
  • playing a critical role in inflammatory and apoptotic responses
  • negatively regulating COL2A1
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional activator
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRAF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Parkinson disease (PARK10)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deletion of Shn2 and Shn3 in mice impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation