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FLASH GENE
Symbol MCCC2 contributors: - updated : 09-03-2007
HGNC name methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
HGNC id 6937
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • carboxyltransferase domain
  • a binding site for the acyl-Coa substrate
  • putative signal peptide
  • secondary structure alpha (biotin containing) and beta subunit
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to Mccb aspergillus midulary
    ortholog to rattus mccc2
    Homologene
    FAMILY accD/PCCB family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalyzing carboxylation of 3 methylcrotonyl COA to form 3 methylglutaconyl-COA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    leucine catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    magnesium Mg2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCC2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS