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FLASH GENE
Symbol GOLGA4 contributors: mct/npt - updated : 03-03-2015
HGNC name golgi autoantigen, golgin subfamily a, 4
HGNC id 4427
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouthtongue  highly
 stomach   highly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil structure stabilized by heptad repeats, granin motif
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD), that associate with the trans-Golgi network (TGN) via a GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN
  • HOMOLOGY
    Homologene
    FAMILY
  • golgin subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • trans Golgi
  • GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
  • ARFRP1 and GOLGA4 were detected in the same compartment close to the nucleus, presumably the trans-Golgi
  • basic FUNCTION
  • Golgi complex antigen targeted by autoantibodies associated with Sjogren syndrome
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements
  • key regulator of TNF secretion and LPS activation of macrophages results in increased Golgi carriers for export
  • coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6x
  • interacting with ARL1
  • CD99 also binds GOLGA4 9)
  • controls the recruitment of proteins such as GOLGA4 to the trans-Golgi
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS