basic FUNCTION
| acting as a vasoconstrictor |
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contributing to diseases including atherosclerosis, cardiac hypertrophy, pulmonary hypertension and tumour growth |
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vasoactive cyclic neuropeptide which activates the G protein-coupled receptor UTS2R, exerts various cardiovascular effects and may play a role in the pathophysiology of atherosclerosis |
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chemoattractant for UTS2R-expressing monocytes and indicate a pivotal role of the RhoA-Rho kinase signaling cascade in the chemotaxis induced by UTS2 |
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having a major role in the pathophysiology of aldosterone-producing adenoma and pheochromocytoma and particularly in a subset of them that have been causally associated with primary aldosteronism |
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having a role in the paracrine interactions between the adrenal medulla and cortex |
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having a role in the pathogenesis and progression of cardiovascular disease |
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intrahepatic UTS2/UTS2R system has an important pathophysiological role in cirrhosis and portal hypertension |
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potential role in glucose homeostasis and diabetes |
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vasoactive peptide associated with vascular remodeling in different cardiovascular disorders |
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involved in the TGFB1 mediated mitogenic effect on airway smooth muscle cells |
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most potent vasoconstrictor, having both vasoconstrictor and vasodilatory actions, and both profibrotic and antiapoptotic activity |