Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TEKT3 contributors: mct - updated : 30-11-2010
HGNC name tektin 3
HGNC id 14293
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text widely, weak
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved tektin domain
  • HOMOLOGY
    interspecies homolog to sea urchin tektin A1
    Homologene
    FAMILY
  • occludin/ELL family
  • tektin family
  • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • cilia and centriole formation
  • microtubule-associated cytoskeletal protein expressed primarily in the male germ cell-lineage in centrioles and basal bodies and within ciliary and flagellar doublet microtubules
  • male germ cell-enriched protein that it might perform important roles in male reproductive development and physiology
  • important role in male reproductive development and physiology
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • co-assembling with tubulins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential candidate genes for nonsyndromic asthenozoospermia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • expressed in round spermatids in mouse
  • male mice null for TEKT3 produce sperm with reduced motility (47.2p100 motility) and forward progression, and increased flagellar structural bending defects