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FLASH GENE
Symbol CKMT1A contributors: mct - updated : 07-02-2018
HGNC name creatine kinase, mitochondrial 1A
HGNC id 31736
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer , octamer
HOMOLOGY
Homologene
FAMILY
  • creatine kinase isoenzyme family
  • ATP:guanido phosphotransferase family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the transfer of high energy phosphate from mitochondria to the cytosolic carrier
  • inhibits apoptosis by suppressing the mitochondrial apoptotic pathway
  • is a key regulator of the permeability transition pore (PT-pore) through a complex that is distinct from the classical PT-pore
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text transport of high energy phosphate from mitochondria to cytosolic carrier
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cardiolipin
  • ankyrin repeat domains of ASB9 can associate with the substrate binding site of CMKT1A in a SOCS box-independent manner
  • MECOM promotes CKMT1A expression by repressing the myeloid differentiation regulator RUNX1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    is associated with a poor prognosis in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might serve as a tumor marker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    targeting CKMT1A is thus a promising therapeutic strategy for this MECOM-driven AML subtype that is highly resistant to current treatment regimens
    ANIMAL & CELL MODELS