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FLASH GENE
Symbol RAB23 contributors: mct/pgu - updated : 28-08-2017
HGNC name RAB23, member RAS oncogene family
HGNC id 14263
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
Nervousbrain    
 spinal cord    
Reproductivefemale systemuterus  highly
Urinarykidneynephronrenal capsuleglomerulushighly
Visualeyeretina  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • Ras superfamily of GTP-binding proteins
  • RAB guanosine triphosphatase (GTPase) family of vesicle transport proteins
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • involved in small GTPase mediated signal transduction and intracellular protein transportation
  • participate in central nervous system development
  • acts as a negative regulator of hedgehog (HH) signaling
  • having a function in antagonizing sonic hedgehog signal transduction
  • may play a role in protein turnover in the cilium
  • negatively regulates GLI1 activity in a SUFU-dependent manner
  • is an essential component of the mechanism that transmits asymmetric patterning information from the node to the lateral plate mesoderm (LPM)
  • small guanine nucleotide binding protein that has important effects on physiological signaling from cilia but was not known previously to be essential for ciliary delivery of any cargo
  • dopamine receptors reveal a previously unrecognized mechanism of ciliary receptor targeting and functional role of RAB23 in promoting this process
  • promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
  • serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through RAC1 activity
  • role for RAB23 in transport processes to the primary cilium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with SUFU and inhibits GLI1 function in a SUFU-dependent manner
  • KIF17 needs to bind to regulatory proteins like RAB23 for its ciliary transport, and RAB23 could mediate the transport of KIF17 to the primary cilium
  • cell & other
  • interaction with cilia
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACPS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary gastric tumors
    tumoral     --over  
    in Prostate cancer tissues and cell lines
    tumoral     --over  
    facilitates malignant cell growth and invasion in bladder cancer through the NFKB1 pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as a biomarker that indicates the severity of FSGS
  • RAB23 expression is a useful indicator of metastatic potential for pancreatic duct adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    is a potential therapeutic target for PCa treatment
    cancerendocrinepancreas
    may be a new therapeutic target for pancreatic duct adenocarcinoma
    ANIMAL & CELL MODELS