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FLASH GENE
Symbol PARVA contributors: npt/ - updated : 17-01-2007
HGNC name parvin, alpha
HGNC id 14652
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Nervousnervecranial nerve  highly
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text embryonic development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calponin homology (CH) domains
  • a single alpha-actinin-like-actin-binding domain
  • HOMOLOGY
    interspecies homolog to murine Parva
    homolog to Drosophila CG12533
    homolog to C.elegans pat-6
    intraspecies paralog to PARVB
    paralog to PARVG
    Homologene
    FAMILY
  • parvin family (of focal adhesion proteins)
  • alpha actinin superfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized to focal adhesions
    basic FUNCTION
  • playing probably a role in the regulation of cell adhesion and cytoskeleton organisation
  • actin-binding protein associated with focal contacts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of focal adhesions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin and paxillin LD1 and LD4 motifs
  • with TESK1 (likely regulated by phosphorylation of PARVA, regulates TESK1 activity and subsequent cellular spreading on fibronectin)
  • interacting with ILK (mechanically couples integrin and PARVA for mediating cell adhesion)(Fukuda 2009))
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS