basic FUNCTION
| playing a central role as a tonicity-responsive transcription factor required for kidney homeostasis and function |
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only known mammalian transcription factor that regulates hypertonic stress-induced gene transcription |
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initiating loss of nucleosome(s) by an NFAT5-independent mechanism, but significantly potentiated in the presence of NFAT5 |
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importance of Ser-155 and Ser-158 in the nucleocytoplasmic trafficking of NFAT5 and CSNK1A1 can plays a major role in regulating this process |
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protects cells from osmotic stress |
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role of NFAT5 and CD24 in the homeostasis of T cells under osmostress |
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novel regulator of smooth muscle cell phenotypic modulation |
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DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor |
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is a novel regulator of mammalian anti-pathogen responses |
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role of NFAT5 in cardiac differentiation of stem cells (PMID; |
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regulator of Wnt signaling, and NFAT5 regulation of intestinal cell differentiation may be through inhibition of Wnt/CTNNB signaling |
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has specific functions during T-cell development independent of its role as an osmoprotective transcription factor |
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the specific participation of NFAT5 downstream from the pre-TCR also lends support to the notion that this receptor controls distinct outcomes that are, for the most part, functionally independent |
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transcription factor that protects the kidney from hypertonic stress and also is activated by hypoxia |
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NFAT5 is part of a protective mechanism that limits renal damage induced by ischemia-reperfusion injury (IRI) |
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arterial wall stress controls NFAT5 activity in vascular smooth muscle cells |