basic FUNCTION
| involved in the cross-talk between epithelial and immune cells in the gut |
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has pleiotropic actions, from augmenting the proliferation of T cells and driving the differentiation of B cells into memory cells and terminally differentiated plasma cells to augmenting the activity of natural killer cells |
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serves as a critical helper factor that is required for viral control in CD8+ T cells |
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acts directly on B cells and cooperates with TLR signaling for optimal B cell responses |
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plays a critical role in the expansion and differentiation of the Th cell subsets, Th17 and follicular helper T (T(FH)) cells |
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IL21 and CD40LG collaborate through at least two distinct mechanisms to synergistically promote PRDM1 activation and plasma cells (PCs) differentiation |
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IL21 and CSF2 exhibit cross-regulatory actions on gene regulation and apoptosis, regulating conventional dendritic cells (cDCs) numbers and thereby the magnitude of the immune response |
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IL21 suppresses the development of Th2 cells and functions of polarized Th2 cells |
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critical role of IL21 in breaking immune homeostasis in aplastic anemia (AA) by promoting Th17 cells, activating BM T cells and suppressing Tregs |
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is a type I cytokine essential for immune cell differentiation and function |
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IL21 exerts major effects on B-cell activation and differentiation or apoptosis during humoral immune responses and induces differentiation of na |
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ve B cells and memory B cells into plasma cells |
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IL21 modulates the effector functions of T, B and NK cells, which not only have key roles in antitumoral and antiviral immunity but also in exerting major effects on inflammatory responses promoting the development of autoimmune diseases |
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context-dependent role for IL21 in sustaining effector phenotype CD8 T cells and influencing their migratory properties, accumulation, and functions |
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IL21 may link immune responses to physiological or pathological platelet-dependent processes |
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regulates megakaryocyte development and platelet homeostasis |
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IL21 reinforces humoral immunity by restricting T follicular regulatory (Tfr) cell proliferation |
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is crucial for the development of a robust CD8+ T cell response and has been shown to promote antitumor immunity |