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FLASH GENE
Symbol FZD3 contributors: mct - updated : 10-09-2011
HGNC name frizzled homolog 3 (Drosophila)
HGNC id 4041
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain   highly
Reproductivefemale systemuterus   
 male systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentepidermal secretory cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text hair follicle development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conserved cysteine-rich WNT binding domain
  • HOMOLOGY
    interspecies homolog to murine Fzd3
    Homologene
    FAMILY Wnt receptor family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
  • required for the development of major fiber tracts in the rostral central nervous system
  • essential for maintenance of dividing sympathetic neuroblasts
  • acting at early developmental stages to maintain a pool of dividing sympathetic precursors,and functioning at later stages to promote innervation of final peripheral targets by postmitotic sympathetic neuron
  • WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for WNT ligands
  • intreraction with VANGL2 (role for VANGL2 in the targeting or anchoring of FZD3, suggesting that novel Planar cell polarity mechanisms exist in vertebrates)
  • WNT2 interacts with both FZD3 and FZD9
  • is essential for normal development of the commissural plate and its loss-of-function causes SLIT2-dependent defects in axon midline crossing in the embryonic vertebrate forebrain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
  • to methamphetamine psychosis
  • Variant & Polymorphism SNP FZD3 haplotypes showed strong associations with methamphetamine psychosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fz3(-/-) sympathetic neuroblasts also undergo enhanced apoptosis, which could not be rescued by eliminating the proapoptotic factor, Bax