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FLASH GENE
Symbol CD209 contributors: mct/npt - updated : 13-03-2009
HGNC name CD209 molecule
HGNC id 1641
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/liningendometrium  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cytoplasmic hydrophobic region
  • a SET of tandem repeats (seven complete and one incomplete)
  • a neck region, with up of seven repeats of 23 amino acids each, known to play a major role in the pathogen-binding properties of these proteins
  • an extra-cellular domain consisting of an extended neck region encoded by tandem repeats that support the carbohydrate-recognition domain, which plays a crucial role in influencing the pathogen-binding properties of this antigen (Khoo 2008)
  • C terminal homolog to C-type lectin
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediates transient adhesion with T cells (Geijtenbeek 2000)
  • enables T cell receptor engagement by stabilization of the DC-T cell contact zone (Geijtenbeek 2000)
  • cell surface receptor binding to oligosaccharide ligands found on human tissues as well as on pathogens including viruses, bacteria, and parasites (Feinberg 2005)
  • attachment receptor of dengue virus, mediating transient adhesion of dendritic cells with T cells
  • playing a crucial role in dengue pathogenesis, discriminating between severe dengue fever and dengue hemorrhagic fever
  • recognize a plethora of pathogens, including bacteria, viruses, and parasites
  • playing a role through the Ca2+ binding site in the phagocytosis of E. coli (Iyori 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds ICAM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to dengue fever, severe form
  • to pulmonary tuberculosis
  • Variant & Polymorphism other
  • allele G of variant DCSIGN1-336 was associated with strong protection against dengue fever
  • polymorphisms increasing the risk of pulmonary tuberculosis in addition with PTX3
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyimmunodeficiency 
    an effective microbicide should target both syndecan-3 and CD209 on dendritic cells to prevent HIV transmission
    ANIMAL & CELL MODELS