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FLASH GENE
Symbol ARTN contributors: - updated : 06-01-2007
HGNC name artemin
HGNC id 727
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 stomach    
Endocrineparathyroid    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, lung, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Artn
intraspecies homolog to artemin
Homologene
FAMILY
  • glial cell-lines derived neutrophic factor family of ligand (GDNF)
  • TGF-beta superfamily
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neutrophic factor involved in stimulation of neurite outgrowth, exerting selective effects on pain sensation
  • ligand for the RET receptor and using GFR-alpha 3 as coreceptor
  • activating the GFR alpha 1 RET receptor complex
  • acting as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues
  • promoting the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after treatment by 6 hydroxydopamine in vivo
  • exhibiting neurotrophic activity on mesencephalic dopaminergic and motor neurons
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • neuroblast proliferation
  • neuronal development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for GFRA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS