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FLASH GENE
Symbol WTAP contributors: mct - updated : 13-11-2019
HGNC name Wilms tumor 1 associated protein
HGNC id 16846
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineparathyroid   highly
Nervousnervecranial nerve  highly
Reproductivemale systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Wtap
homolog to drosophila female-lethal-2-D
Homologene
FAMILY
  • FL(2)D family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • partially colocalizing with splicing factor
  • METTL3/METTL14 is found in the nucleus where it is localized to nuclear speckles and the splicing regulator WTAP is required for this distinct nuclear localization pattern
  • basic FUNCTION
  • involved in the morphogenesis of the genitourinaty tract
  • essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition
  • WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation
  • WTAP may function as a regulatory subunit in the m6A methyltransferase complex and play a critical role in epitranscriptomic regulation of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryonal development, sperm production
    PATHWAY
    metabolism
    signaling
    a component
  • RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis
  • trimer N-6-methyltransferase METTL3-METTL14-WTAP complex is linked to such critical biological processes as cell differentiation, proliferation, and death
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WT1 (C terminus)
  • activity of epidermal growth factor receptor can be regulated by WTAP
  • WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly up-regulated in hepatocellular carcinoma significantly up-regulated and promotes liver cancer development
    tumoral     --over  
    in glioblastoma which is regarded as a grade IV astrocytoma
    tumoral     --over  
    in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a novel prognostic marker in glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    WTAP is a potential therapeutic target of HCC treatment
    ANIMAL & CELL MODELS