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FLASH GENE
Symbol SLC7A10 contributors: npt/ - updated : 01-09-2005
HGNC name solute carrier family 7, (cationic amino acid transporter, y+ system) member 10
HGNC id 11058
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Nervousbrain   highly
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4, the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Asc1
    intraspecies homolog to LAT2
    Homologene
    FAMILY
  • solute carrier family 7
  • amino acid-polyamine-organocation (APC) superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • transport of small neutral amino acids including the D isomers, in particular D-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2hc/CD98 (MDU1) at the basolateral membrane to form a complex mediating y(+)L-type transporter
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene cystinuria
    Marker
    Therapy target
    ANIMAL & CELL MODELS