protein
| MAP3K7 |
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binding partner of EDARADD |
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interacting with NUMBL |
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putative MAP3K7 interacting protein involved in the regulation of MAP3K7, that could directly interact with NLK and function as a scaffold protein to facilitate the interaction between MAP3K7 and NLK |
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binds adjacent ubiquitin moieties via two distinct binding sites |
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relationship between two central regulatory pathways in which MAP3K7-MAP3K7IP1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes MAP3K7 signalling by dephosphorylation of MAP3K7 and MAP3K7IP1 |
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TAB2 and TAB3 bind to BECN1 and colocalize in the cytoplasm |
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TAB2 also interacts with ATG13 and is phosphorylated by ULK1 |
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existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with NR2C2 |
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SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6 |
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TRAF5 negatively regulated the association of TAB2 with its signaling partner TRAF6 after TLR ligation in B cells |
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TAB2 is a sensor of stress conditions in the liver and functions to protect the liver by activating the MAP3K7 pathway |
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RNF4 specifically down-regulated TAB2 through a lysosomal pathway |
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RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1 |