basic FUNCTION
| catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP) involved in a variety of cellular processes |
|
enhanced by exposition to mitogenic agents |
|
playing an essential role in neural and vascular development |
|
lipid kinase implicated in mitogenic signaling pathways in vascular smooth muscle cells |
|
cytosolic enzyme that is recruited to the plasma membrane following its phosphorylation in response to growth stimuli |
|
role of SPHK1 and its product SGPP1 in TNF1 signalling and the canonical NFkB activation pathway important in inflammatory, antiapoptotic and immune processes |
|
implicated DEFB4A regulation in oral keratinocytes |
|
its over-expression in human endothelial cells promotes, in part, their de-differentiation to a progenitor cell phenotype, and is thus a potential tool for the generation of a large population of vascular progenitor cells |
|
plays a critical role in matrix accumulation in glomerular mesangial cells |
|
under diabetic condition |
|
SPHK1/S1P signaling plays an important role in regulating early events during development of sensory ganglia |
|
key enzyme in the sphingolipid metabolic pathway, forming an essential checkpoint to regulate the relative levels of bioactive sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate (S1P) |
|
SPHK1 acetylation plays a key role in cell growth, cell size, and cell-cycle control |
|
SPHK1-produced S1P is a crucial mediator of breast cancer-induced hemangiogenesis and lymphangiogenesis |
|
endothelial SKPH1 is an important contributor to allergic inflammation |
|
important role for S1PR4 and SPHK1 in oestrogen receptor-negative breast cancer progression |
|
its activation is involved in the regulation of lipopolysaccharide-induced brain injury |
|
important enzyme involved in the production of the bioactive lipid sphingosine 1-phosphate (S1P) |