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FLASH GENE

Symbol

HMGN5

contributors: mct - updated : 06-06-2013

HGNC name	high mobility group nucleosome binding domain 5
HGNC id	8013

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol   fibroblast   stromal cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminus a bipartite nuclear localization signal (NLS)
	a HMG-14/17 signalure including the nucleosomal binding domain
	an acidic C-terminal domain that differs among vertebrate species

HOMOLOGY

interspecies

homolog to murine Nsbp1

intraspecies

homolog to HMG14/17

Homologene

FAMILY

HMGN family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome,nucleosome
	intracellular,nucleus,nucleolus
text	specifically targeted by its C-terminal domain to nucleosomes in euchromatin

basic FUNCTION	nucleosome binding protein that modulates the expression of prolactin gene family members most likely by inducing changes in chromatin structurev
	nuclear protein which binds to nucleosomes via the nucleosomal binding domain, unfolds chromatin, and affects transcription
	may play a critical role in the development of gliomas
	nucleosome-binding architectural protein that affect the structure and function of chromatin
	has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription
	promotes the viability of bladder cancer cells through increased cell proliferation but not decreased apoptosis, and increases the invasion ability of metastatic bladder cancer cells through the upregulation of MMP9 activity

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction with nucleosomes alters the compaction of cellular chromatin and in living cells, HMGN5 interacts with linker histones
	interaction of HMGN5 with nucleosomes alters the compaction of cellular chromatin and that in living cells, NSBP1 interacts with linker histonesinteract with histone H1, reduce its chromatin residence time, and can induce large-scale chromatin decompaction in living cells
	binds to nucleosomes and regulates gene transcription through chromatin remodeling
	N-terminal domain of HMGN5 interacts with the C-terminal domain of TMPO and these proteins reciprocally alter their interaction with chromatin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer tumoral     --over   in both high-grade and low-grade glioma tissue samples compared with normal brain tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer urinary   NSBP1 RNAi as a novel therapeutic approach for bladder cancer cancer reproductive prostate downregulation of HMGN5 gene can inhibit the proliferation of prostate cancer cells

ANIMAL & CELL MODELS