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FLASH GENE
Symbol FGFRL1 contributors: npt/ - updated : 21-09-2007
HGNC name fibroblast growth factor receptor-like 1
HGNC id 3693
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 pancreas    
Reproductivefemale systemovary  highly
 male systemprostate  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Connectivecartilage  highly
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text bone, vertebrae, muscle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • signal peptide
  • three extracellular Ig-like domains that were related to the members of the fibroblast growth factor (FGF) receptor family
  • a transmembrane segment (TM) and a short intracellular domain
  • HOMOLOGY
    interspecies homolog to murien FgfrL1
    Homologene
    FAMILY
  • fibroblast growth factor receptor family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • modulator of FGF receptor activity during chondrocyte differentiation and enchondral ossication
  • acting as a decoy receptor for FGF ligands
  • involved in the control of cell proliferation and differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression might contribute to the development and progression of ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for facial features in WHS
  • candidate gene for the diaphragmatic defects
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
    Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm (Lopez Jimenez 2010)