basic FUNCTION
| promotes the formation of stable actin filament structures such as stress fibers at the expense of more dynamic actin filament structures such as membrane ruffles |
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functions to link the cadherin-catenin complex to F-actin and simultaneously stabilizes this population of actin fibers, resulting in the establishment of the adhesion belt |
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actin-binding protein that functions as a key molecule linking the cadherin-catenin complex to the actin cytoskeleton |
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may function during cytokinesis to maintain local accumulation of key cytokinesis proteins at the furrow |
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cytoskeletal target gene transcriptionally regulated by the actin-MKL1-SRF pathway, which supports a role in cancer biology |
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could function as a suppressor of tumor metastasis by negatively regulating EMT in Prostate carcinoma cells |
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may contribute to the motility of invasive tumor cells |
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negative regulator of epithelial-mesenchymal transition and invasiveness in prostate cancer cells |
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functions to maintain the zonula adherens via its association with CTNNA1, but was lost in the punctate adherens junctions |
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epithelial cells remodel their junctional architecture by responding to mechanical forces, and CTNNA1-bound LIMA1 acts as a mechanosensitive regulator for this process |
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establishes a link between the cadherin·catenin complex and actin that is independent of actomyosin tension |
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necessary for stabilization of capillary structures in an angiogenesis model |
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EPLIN-& |
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945; is a tumour suppressor of oesophageal cancer |