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FLASH GENE
Symbol CHRM4 contributors: mct - updated : 17-11-2011
HGNC name cholinergic receptor, muscarinic 4
HGNC id 1953
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrainforebrain  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies ortholog to rattus Chrm4
ortholog to murine Chrm4
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • regulate the dynamics of cholinergic and dopaminergic neurotransmission
  • regulate the dynamics of cholinergic and dopaminergic neurotransmissionneuronal CHRM4 plays a critical role in modulating several important dopamine-dependent behaviors
  • CHRM1, and CHRM4, are the major muscarinic ACh receptors subtypes responsible for direct cholinergic modulation of the excitatory hippocampal circuit
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAMK2A binds directly and selectively to one of five mAChR subtypes, CHRM4, at its C-terminal regions of second intracellular loops
  • cell & other
    REGULATION
    Other regulated by CAMK2A (in a Ca(2+)-sensitive manner, regulates CHRM4 efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurology  
    M4 receptor agonists could represent an innovative strategy for the treatment of pathologies associated with hyperdopaminergia
    ANIMAL & CELL MODELS