protein
| inhibiting the function of CASP3, CASP7 and CASP9 key effector proteases of apoptosis |
|
XAF1 binds directly to the N-terminal proline-rich domain of TP53 and thus interferes with E3 ubiquitin ligase MDM2 binding and ubiquitination of TP53 |
|
XAF1 is involved in BRD7-associated senescence and plays an important role in the regulation of endothelial senescence through a TP53-dependent pathway. 8) |
|
binds to XIAP and blocks its anti-apoptotic activity |
|
XAF1 is likely a downstream target of KIF1B beta |
|
XAF1 interacts with TRAF2 and inhibits TRAF2-dependent NFKB1 activation, in part, by blocking TRAF2 polyubiquitination |
|
XAF1 acts as a feedback regulator of the TNF receptor signaling pathway to suppress NFKB1 activation |
|
macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNB1, which induced beta-cell apoptosis by increasing the expression of XAF1 |
|
functions as a transcriptional coactivator of IRF1 to suppress tumorigenesis |
|
YY1 is able to mediate XAF1 silencing |
|
SARM1 deficiency exacerbates the progression of prion pathogenesis, by up-regulating XAF1, which promotes neuronal apoptosis, and accelerates prion disease |
|
TGFB1 protects colon tumor cells from apoptosis through XAF1 suppression |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
low expressed by aberrant promoter methylation in gastric adenocarcinoma in progression | tumoral
|  
|  
|  
|  
|
by hypermethylation in prostate, kidney and bladder carcinoma, in malignant progression | tumoral
|  
|  
| --over
|  
|
significantly reduced invasion and migration of SKOV3 cells (ovarian cancer), and inhibited vascular endothelial growth factor protein expression | tumoral
|  
|  
| --over
|  
|
impairs neuroblastoma tumor progression | tumoral
|  
|  
| --low
|  
|
implicated in clear-cell renal cancer progression | |