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FLASH GENE
Symbol ADAMTS9 contributors: mct - updated : 24-01-2019
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 9
HGNC id 13202
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Hearing/Equilibriumear   predominantly
Nervousbrain    
 nerve   highly
 spinal cord    
Reproductivefemale systemovary   
Respiratorylung    
 respiratory tractlarynx  moderately
Urinarykidney    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text ubiquitous
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 18 aa signal sequence of 2.1 kda
  • a peptidase M12B
  • a disintegrin-like domain
  • fifteen thrombospondin type 1 (TSP1) domains
  • a spacer domain without cysteine residue
  • a unique C-terminal domain called the "GON domain"
  • conjugated GlycoP , MetalloP
    isoforms Precursor a 1917 aa proprotein of 214.4 kda given a 1648 aa mature protein of 184.2 kda
    HOMOLOGY
    interspecies homolog to C.elegans Gon1
    homolog to rattus Adamts9 (88.2 pc)
    homolog to murine Adamts9
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY chaperone/stress , enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • proteinaceous extracellular matrix
  • localizes near basal bodies of primary cilia, and endocytosis is required for the localization of ADAMTS9 near the basal bodies
  • basic FUNCTION
  • cleaving the large aggregating proteoglycans, aggrecan and versican
  • acting as an intramolecular chaperone whose glycosylation is critical for secretion of the mature enzyme (propeptide activity)
  • is a putative tumor suppressor gene in nasopharyngeal carcinoma (NPC) that is significantly associated with lymph node metastases
  • participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer
  • ADAMTS9 is a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously in ECs via molecular mechanisms that are distinct from those used by ADAMTS1
  • novel function of ADAMTS9 in the ER that promotes protein transport from the ER to the Golgi (this function is GON-domain dependent but protease activity independent)
  • is a critical tumor suppressor of gastric cancer progression at least in part through suppression of oncogenic AKT/MTOR signaling
  • potential role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism protein
    signaling
    glycoprotein catabolic process
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (1 ion per subunit)
  • protein
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • is a cytokine-inducible gene that contains binding sites for NFKB1 within its promoter region
  • NFKB1 may be involved in IL1B-induced activation of ADAMTS9 in human chondrocytes
  • cell & other
    REGULATION
    induced by the pathways MAPK and NFKB, thought to be responsible pathways for the induction of ADAMTS9 gene
    Other precursor cleaved by a furin endopeptidase
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHP21
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in hereditary renal tumors
    tumoral        
    in gastric cancer cell lines
    tumoral        
    by epigenetic disruption in colorectal cancer
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other
  • ADAMTS9 genetic risk variants were associated with type 2 diabetes
  • ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    ADAMTS9 is a potential novel mode of treating insulin resistance.
    ANIMAL & CELL MODELS
  • mice lacking Adamts9 selectively in skeletal muscle have improved insulin sensitivity