SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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text
| proteinaceous extracellular matrix |
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localizes near basal bodies of primary cilia, and endocytosis is required for the localization of ADAMTS9 near the basal bodies |
basic FUNCTION
| cleaving the large aggregating proteoglycans, aggrecan and versican |
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acting as an intramolecular chaperone whose glycosylation is critical for secretion of the mature enzyme (propeptide activity) |
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is a putative tumor suppressor gene in nasopharyngeal carcinoma (NPC) that is significantly associated with lymph node metastases |
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participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer |
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ADAMTS9 is a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously in ECs via molecular mechanisms that are distinct from those used by ADAMTS1 |
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novel function of ADAMTS9 in the ER that promotes protein transport from the ER to the Golgi (this function is GON-domain dependent but protease activity independent) |
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is a critical tumor suppressor of gastric cancer progression at least in part through suppression of oncogenic AKT/MTOR signaling |
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potential role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican |