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FLASH GENE
Symbol STAG3 contributors: mct - updated : 30-09-2020
HGNC name stromal antigen 3
HGNC id 11356
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 tonsils   highly
Nervousnervecranial nerve  highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
life cycle division
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
specific stromalin conservative domain (SCD)
HOMOLOGY
Homologene
FAMILY
  • stromalin family
  • SCC3 family
  • CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,chromatin/chromosome
    text synaptonemal complex
    basic FUNCTION
  • chromosome pairing and maintenance of synaptonemal complex structure during the pachytene phase of meiosis
  • meiosis-specific cohesin subunits, forming complexes involved in the maintenance of sister chromatid cohesion during division of somatic and germ cells with a sexual dimorphism in sister chromatid cohesion in meiosis
  • dynamics of cohesins REC8, STAG3, SMC1B and SMC3 suggest their participation in sister chromatid cohesion throughout the whole meiotic process in human oocytes
  • meiosis-specific subunit of the cohesin complex, a large proteinaceous ring with DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis and segregation of homologous chromosomes during meiosis
  • STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin
  • STAG3 is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis
  • is a novel regulator of microtubule dynamics to ensure euploidy during mouse oocyte meiotic maturation
  • STAG3 is a stromalin subunit common to all meiosis-specific cohesin complexes
  • encodes for a meiosis-specific protein that is crucial for the functionality of meiotic cohesin complexes
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRDM9 interacts with STAG3 and REC8 in cooperative relationships that promote normal levels of meiotic DSBs at recombination hotspots in spermatocytes
  • PHB in spermatocytes regulates the expression of STAG3, a key component of the meiotic cohesin complex, via a non-canonical JAK/STAT pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF8 , SPGF61
    Susceptibility to male infertility
    Variant & Polymorphism other
  • two compound-heterozygous variants in STAG3 (c.[1262T>G];[1312C>T], p.[(Leu421Arg)];[(Arg438Ter)]) have been found to cause male infertility due to complete bilateral meiotic arrest in an otherwise healthy human male
  • Candidate gene
  • STAG3 is a strong candidate gene for human male infertility
  • Marker
    Therapy target
    ANIMAL & CELL MODELS