Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PCBP3 contributors: mct - updated : 26-01-2013
HGNC name poly(rC) binding protein 3
HGNC id 8651
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
RNA binding protein with three k homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
HOMOLOGY
Homologene
FAMILY
  • PCBP family, KH-domain protein subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • post-transcriptional control
  • can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level
  • modestly activates splicing of MAPT exon 10 by interacting with its proximal downstream intron , suggesting a pathogenic role of PCBP3 and other splicing factors on chromosome 21 in neurodegenerative diseases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS