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FLASH GENE

Symbol

PFDN4

contributors: npt/ - updated : 25-06-2008

HGNC name	prefoldin subunit 4
HGNC id	8868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas       highly Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, interphase, G1, S

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains

helix-loop-helix (HLH) motif

mono polymer

heteromer , hexamer

HOMOLOGY

Homologene

FAMILY

prefoldin beta subunit family

CATEGORY

chaperone/stress , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	assisting in the correct folding of other proteins
	transfering target proteins to cytosolic chaperonin (C-CPN)
	promoting folding in an environment in which there are many competing pathways for nonnative proteins
	playing a role during G1-S phase transition phase of the cell cycle
	promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins

CELLULAR PROCESS	nucleotide, transcription
	protein, editing
	protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterohexamer of two PFD-alpha type and four PFD-beta type subunits

INTERACTION

DNA

binding

RNA

small molecule

protein

binding specifically to cytosolic chaperonin (C-CPN)binding to nascent polypeptide chain

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS