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FLASH GENE
Symbol TOMM20 contributors: mct - updated : 05-02-2018
HGNC name translocase of outer mitochondrial membrane 20 homolog (yeast)
HGNC id 20947
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineparathyroid   moderately
Hearing/EquilibriumearinnercochleaCortimoderately Homo sapiens
Nervousbrain   moderately
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumcochlea cell Homo sapiens
Hearing / Equilibriumhair cell receptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane segment containing critical AAs essential for docking the TOMM20 receptor into its correct environment within the TOM complex
  • N-terminal TOMM20-binding element essential for targeting to mitochondria
  • C-terminal element increasing efficiency of protein import in the step prior to translocation across the inner membrane
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Mas20p
    ortholog to rattus Tomm20 (97.9pc)
    ortholog to murine Tomm20 (99.3pc)
    ortholog to Drosophila Tom20 (59.4pc)
    Homologene
    FAMILY
  • TOM20 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • mitochondrial outer membrane translocase complex
  • distributions of clusters of TOMM20 and of TOMM22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria
  • basic FUNCTION
  • import receptor involved in the recognition and translocation of cytosolically synthesized mitochondrial preproteins
  • functioning with TOMM22 as the transit peptide receptor at the surface of the mitochondrion outer membrane
  • facilitating the movement of preproteins into the TOMM40 translocation pore
  • major import receptor that recognizes preferentially mitochondrial presequences
  • apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import as TOMM22
  • master receptor for protein import into mitochondria
  • recognizes the targeting sequence on incoming mitochondrial precursor proteins, binds these protein ligands, and then transfers them to the core complex for translocation across the outer membrane
  • mediates localization of mRNAs to mitochondria in a translation-dependent manner
  • plays an essential role in specificity of mitochondrial protein import
  • has a dual role in protein import into mitochondria: recognition of the targeting signal in the presequence and tethering the presequence to the TOMM40 complex to increase import efficiency
  • functions as a receptor for the N-terminal presequence of mitochondrial-precursor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mitochondrial import complex
  • central component of a mitochondrial receptor complex
  • mitochondrial outer membrane translocase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TOMM22 and leader sequence of nuclear coded matrix space precursor proteins
  • competes with the chaperones for TOMM70A binding
  • AIP-TOMM20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of BIRC5
  • FBXO7 ubiquitinated TOMM20, and its levels correlated with FBXO7 expression, indicating a stabilizing effect
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neoplastic lymphocytes 2)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TOMM20 can be used in the inner ear as a marker for mitochondrial protein import
  • Therapy target
    ANIMAL & CELL MODELS