basic FUNCTION
| premRNA splicing |
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coordinating histone methylation and transcriptional regulation |
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having a potential roles in hematopoiesis and pathogenesis of Huntington disease |
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histone methyltransferase specific for lys-36 of histone H3 |
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probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POL2RA |
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may act as a transcription activator that binds to promoters |
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can interact with TP53 and selectively regulate its transcription factor activity (Xie 2008) |
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may be a tumor suppressor for breast cancer (Al Sarakbi 2009) |
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histone methyltransferase that is involved in transcriptional elongation |
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SETD2 function of histone methylation could be the missing link in this chain which could explain the potential tumour suppressor function of SETD2 (20944102) |
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both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark |
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essential role of SETD2 in myoblast proliferation and differentiation |