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FLASH GENE
Symbol ATP6V0A4 contributors: npt/ - updated : 05-02-2007
HGNC name ATPase, H+ transporting, lysosomal V0 subunit a4
HGNC id 866
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Reproductivemale systemprostate   
UrinarykidneytubuleHenles loop  
 kidneytubuleconvoluted tubuleproximal tubule 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensorystato-auditory  
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarytubular cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal hydrophilic intracellular region
  • a catalytic domain
  • six putative transmembrane segments
  • a cytoplasmic C terminal tail
  • mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Atp6v0a4
    intraspecies homolog to ATP6N1A,OC116
    Homologene
    FAMILY
  • V-type ATPases family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text apical surface of alpha intercalated cells
    basic FUNCTION
  • multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles
  • contributing to neurotransmitter accumulation in synaptic vesicles first, and then release from these organelles during synaptic activity
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text proton pump that acidify intracellular compartments
    PATHWAY
    metabolism
    signaling
    a component
  • component of the heteromultimeric complex composed of a peripheral catalytic V1 complex attached to an integral V0 membrane pore complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DRTAB2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS