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FLASH GENE
Symbol SLC19A3 contributors: mct - updated : 21-12-2011
HGNC name solute carrier family 19, member 3
HGNC id 16266
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane spanning segments
  • cytoplasmic N and C termini
  • HOMOLOGY
    interspecies homolog to murine Slc19a3
    Homologene
    FAMILY
  • reduced folate family of micronutrient transporter genes
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transporter for the intake of folate, reduced folate and methotrexate
  • may contribute to resistance to apoptosis in the tumors
  • uptake of thiamine was adaptively regulated by extracellular substrate level via transcriptionally mediated mechanisms that involve both SLC19A2 and SLC19A3
  • required for normal uptake of thiamin in the intestine and can fulfill normal levels of uptake in conditions associated with SLC19A2 dysfunction
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS facilitated diffusion transport , active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • biotin is not a substrate for SLC19A3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BBGD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    promoter hypermethylation in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant SLC19A3 promoter hypermethylation in plasma may be a novel biomarker for breast and gastric cancer diagnosis
  • methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development
  • Therapy target
    ANIMAL & CELL MODELS
  • intestine of THTR-2-deficient mice had reduced uptake of thiamin compared with those of wild-type littermate mice