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FLASH GENE
Symbol SLC2A6 contributors: KTN/npt - updated : 07/11/2008
HGNC name solute carrier family 2 (facilitated glucose transporter), member 6
HGNC id 11011
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveesophagus   moderately
 pancreas exocrine   moderately
Endocrineplacenta   moderately
Lymphoid/Immunespleen   predominantly
 tonsils   highly
Nervousbrain   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane segments
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loops, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog SLC2A6 (87.9 pc)
    homolog to chimpanzee SLC2A6 (99.6 pc)
    homolog to cow SLC2A6 (87.2 pc)
    homolog to rattus Slc2a6 (83.4 pc)
    homolog to murine Slc2a6 (83.4 pc)
    Homologene
    FAMILY
  • solute carrier family 2
  • major facilitator superfamily
  • sugar transporter (TC 2.A.1.1) family
  • glucose transporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a facilitated glucose transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text sugar transport (sugar:hydrogen symporter)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS