basic FUNCTION
| liver specific transport protein |
|
play crucial roles in the renal secretion of various drugs |
|
facilitative transporter for cGMP and other guanine nucleotides |
|
may be involved in the regulation of cellular metabolism through the transport of short chain fatty acid propionate in the kidneys and the liver |
|
operates as glutamate efflux transporter, and catalyses uptake of orotic acid |
|
SLC22A7 is a likely relevant creatinine transporter and further challenging the traditional view that creatinine is solely transported by a cationic pathway |
|
important role of SLC22A7 in renal secretion and possible reabsorption of creatinine |
|
is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically important endogenous compounds |
|
marked interindividual variability likely in the hepatic expression of SLC22A7/SLC22A9, which may contribute to the pharmacokinetic variability of their substrates |