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FLASH GENE
Symbol OGN contributors: mct - updated : 27-01-2014
HGNC name osteoglycin (osteoinductive factor, mimecan)
HGNC id 8126
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta  highly Mus musculus
Endocrineneuroendocrinepituitary    Homo sapiens
 parathyroid    
Hearing/Equilibriumearinnercochlea highly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumcochlea cell Mus musculus
not specificchondrocyte Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four leucine-rich repeats flanked by cysteine-rich regions
HOMOLOGY
interspecies homolog to murine Ogn
Homologene
FAMILY small leucine-rich proteoglycan family,class III
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,lysosome
text extracellular matrix
basic FUNCTION
  • inducing bone formation in conjunction with transforming growth factor beta (TGFB1, TGFB2)
  • pituitary secretory protein, playing an important role in the regulation of cellular growth
  • may be modifiing the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis
  • its downregulation is a fundamental requirement for proper arteriogenesis
  • important regulator of left ventricular mass through modulation of the TGF-beta pathway
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • may be a crucial humoral bone anabolic factor that is produced by muscle tissues
  • may be an important factor produced by muscle-derived cells and secreted into blood that exhibits bone anabolic effects
  • might play an important role in bone formation by osteoblasts at the well differentiated stage
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS development
    text bone formation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OGN expressed in pituitary corticotroph cells mainly regulates ACTH secretion in the pituitary and coordinates the hypothalamo-pituitary-adrenal axis (HPAA)
  • cell & other
    REGULATION
    Other regulated by pituitary transcription factor-1 (POU1F1) as a marker for diagnosing pituitary tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    its overexpression antagonized BMP2-induced differentiation of myoblastic cells into osteoblasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ogn-deficient mice, have normal hearing thresholds