basic FUNCTION
| acting as an histone acetyltransferase involved in transcriptional activation |
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required specifically for the maintenance of H4K16 acetylation and normal chromatin architecture of all cells of early male and female embryos |
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through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair |
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major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution |
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involved in H4 K16 acetylation and playing an important roles in DNA damage repair by modulating recruitment of DNA damage repair protein MDC1 |
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modulates proliferation and metastasis by regulating histone H4K16 acetylation at the promoter regions of downstream target genes |
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major enzyme that catalyzes the acetylation of histone H4 on lysine 16 |
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play an essential role in maintaining normal cell functions |
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KAT8-mediated NFE2L2 acetylation and nuclear retention are essential for anti-oxidative and anti-drug responses |
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participates in human hepatocellular carcinoma by targeting SIRT6 |