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FLASH GENE
Symbol FADS1 contributors: mct - updated : 16-12-2021
HGNC name fatty acid desaturase 1
HGNC id 3574
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
 vesselartery    Homo sapiens
Digestiveesophagus     Homo sapiens
Endocrinethyroid     Homo sapiens
Nervousnerve     Homo sapiens
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
Nervousautonomous  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cytochrome b5-like domain
  • three histidine-rich region
  • a C terminal multiple membrane spanning desaturase portion
  • two membrane spanning domains
  • conjugated HemoP
    HOMOLOGY
    intraspecies paralog to FADS2
    paralog to FADS3
    Homologene
    FAMILY
  • member of the fatty acid desaturase (FADS) gene family, cytochrome B5 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • regulating unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain
  • catalyzing production of polyenoic fatty acids such as arachidonic acid
  • association of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes
  • ability of FADS1 to reciprocally regulate lipogenesis and inflammation may rely in part on its role as an effector of liver X receptor signaling
  • is an underappreciated regulator of inflammation initiation and resolution
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid desaturation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization
    tumoral     --low  
    suggests pessimistic prognosis for non-small-cell lung cancer (NSCLC) patients
    Susceptibility
  • to risk of coronary artery disease (CAD) in diabetic patients
  • Variant & Polymorphism SNP
  • SNPs in FADS1 gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both T2D and coronary artery disease (CAD), which maybe increases the risk of CAD in diabetic patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS