basic FUNCTION
| acting as a putative regulator of gene expression in T cells and immature thymocytes and of cytokines to suppress local aberrant growth of vessels |
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inducing chondrogenesis and chondrocyte gene expression |
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required for cardiac development and mitochondrial function |
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calcineurin/NFATC3 signaling pathway regulates the expression of the 1 subunit of Ca2+-activated K+ (BK) channel in arterial smooth muscle and plays a critical role in the development of angiotensin II-induced hypertension |
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translocates to the nucleus in response both to a slow and to a fast-like pattern of activity (Calabria 2009) |
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transcriptionally active in fast muscles, i.e., in response to less frequent calcium transients and, presumably, lower Calcineurin activity (Calabria 2009) |
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transcription factor tightly regulated by the calcium/calmodulin-dependent phosphatase, calcineurin, activated in astrocytes applied with calcium ionophore or APP ( |
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positive feedback control between STIM1/SOCE and NFATC3 is required for efficient induction and progression of myoblast differentiation |
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NFATC2, NFATC3 possess distinct nuclear localization dynamics in response to cell stimulation |
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important and novel regulatory mechanisms of NFATC3 activation in in pulmonary arterial smooth muscle cells (PASMC) by ROS |
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transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells (pDCs) |